|
Message Board >
Cyclopropanecarbonyl chloride
Cyclopropanecarbonyl chloride
Page:
1
samir123
Guest
Apr 14, 2025
11:13 PM
|
Introduction
Cyclopropanecarbonyl chloride
chloride (CPCC) is a valuable reagent in organic and medicinal chemistry, particularly for the synthesis of complex pharmaceutical compounds and advanced materials. Known for its reactive acid chloride group and strained cyclopropane ring, CPCC plays a crucial role in introducing the cyclopropylcarbonyl moiety into various chemical structures, enhancing biological activity and structural diversity.
Chemical Identity
IUPAC Name: Cyclopropanecarbonyl chloride
Other Names: CPCC, Cyclopropylcarbonyl chloride
Molecular Formula: C4H5ClO
Molecular Weight: 104.53 g/mol
CAS Number: 4023-34-1
Appearance: Clear to pale yellow liquid
Boiling Point: ~130-132 °C
Density: ~1.14 g/cm³
Structure and Reactivity
Cyclopropanecarbonyl chloride consists of a cyclopropane ring attached to a carbonyl chloride group. The ring strain in cyclopropane makes the molecule more reactive, while the acid chloride group serves as a key functional handle for acylation reactions.
It readily reacts with:
Amines to form cyclopropanecarboxamides
Alcohols to form esters
Hydrazines and hydroxylamines for various heterocyclic transformations
Applications of CPCC
1. Pharmaceutical Intermediate
CPCC is widely used in the synthesis of cyclopropyl-containing drugs, especially those requiring the cyclopropylcarbonyl group for increased metabolic stability and bioactivity. It serves as a precursor in:
Antiviral drugs
Antibacterial agents
Anti-inflammatory compounds
2. Agrochemical Synthesis
Cyclopropyl moieties are common in agrochemicals, where they enhance lipophilicity and membrane penetration. CPCC is employed in synthesizing:
Herbicides
Insecticides
Fungicides
3. Specialty Chemicals and Materials
Due to its unique ring strain, CPCC finds use in polymer chemistry and materials science, contributing to novel monomers and structural motifs.
4. Peptide and Protein Modification
In peptide chemistry, CPCC can be used for selective N-acylation, adding structural rigidity and lipophilicity to bioactive peptides.
Handling and Storage
Store in cool, dry, and well-ventilated conditions
Keep away from moisture and open flames
Use proper PPE (gloves, goggles, lab coat)
Best handled under inert atmosphere (e.g., nitrogen or argon)
Safety and Regulatory Information
Hazard Class: Corrosive, Irritant
Hazard Statements: Causes skin burns and eye damage; harmful if inhaled
First Aid Measures: In case of contact, rinse with water for 15+ minutes; seek medical attention
Regulatory Compliance: Follow local and international chemical handling and transportation regulations
Conclusion
Cyclopropanecarbonyl chloride (CPCC) is a highly useful chemical intermediate with wide-ranging applications in pharmaceuticals, agrochemicals, and fine chemical synthesis. Its dual functionality — the reactive acyl chloride group and the strained cyclopropane ring — provides enhanced reactivity and structural benefits to the final products.
Looking to procure CPCC? Reach out to us for bulk quantities, technical data sheets (TDS), MSDS, and global shipping options tailored to your research or production needs.
|
Post a Message
Real Estate Provider #515.000066/Fahim Muhammad Instructor #512.003026/Fahim Muhammad Managing Broker #471.020985 Freedom Financial Institute, IDOI Provider #500026517/NMLS Provider #1405073/Fahim Muhammad NMLS #1851084 All loans originated through Mortgage Loan Direct, NMLS #1192858 15255 South 94th Avenue, Suite 500 Orland Park, IL 60462. Freedom Apex Enterprise & Financial Services Mailing Address: 837 East 162nd Street, Suite 7-8 South Holland, IL 60473 708-704-7309/708-566-1222, 844-49-FREEDOM
FINRA Broker Check
Disclaimer and Release Nothing contained on this website constitutes tax, legal, insurance or investment advice, or the recommendation of or an offer to sell, or the solicitation of an offer to buy or invest in any investment product, vehicle, service or instrument.The information shared is hypothetical and for informational and educational purposes only. Such an offer or solicitation may only be made and discussed by a registered representative of a broker dealer or investment advisor representative of an investment advising firm. You should note that the information and materials are provided "as is" without any express or implied warranties. Past performance is not a guarantee of future results. All investments involve a degree of risk, including a degree of loss. No part of FTAMG’s materials may be reproduced in any form, or referred to in any other publication, without express written permission from FTAMG and or its affiliates. Links to appearances and articles by Fahim Muhammad, The Freedom Coach, whether in the press, on television or otherwise, are provided for informational and educational purposes only and in no way should be considered a recommendation of any particular investment product, vehicle, service or instrument or the rendering of investment advice, which must always be evaluated by a prospective investor in consultation with his or her own financial adviser and in light of his or her own circumstances, including the investor's investment horizon, appetite for risk, and ability to withstand a potential loss of some or all of an investment's value. By using this website, you acknowledge that you have read and understand the foregoing disclaimers and release FTAMG and its affiliates, members, officers, employees and agents from any and all liability whatsoever relating to your use of this site, any such links, or any information contained herein or in any such appearances or articles (whether accessed through such links or downloaded directly from this website). FTAMG highly encourages its viewers and potential clients to obtain the independent advice and services of legal, financial, and tax professionals.
Securities offered through The Leaders Group, Inc. member FINRA/SIPC 475 Springfield Avenue, Suite 1 Summit, NJ 07901 (303) 797-9080
info@freedomfinancialinstitute.orgCopyright© 2025 - Fahim Muhammad Freedom Financial Institute, Inc.
|
|
|
