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3-Bromoaniline: Applications, Properties, and Indu
3-Bromoaniline: Applications, Properties, and Indu
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samir35
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Apr 18, 2025
2:02 AM
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Introduction
3-Bromoaniline
is an important intermediate compound in the field of organic synthesis, pharmaceutical development, and dye manufacturing. With its distinctive chemical structure and reactivity, it serves as a foundational building block for the production of various fine chemicals, agrochemicals, and active pharmaceutical ingredients (APIs).
Chemical Identity
IUPAC Name: 3-Bromoaniline
Other Names: Meta-Bromoaniline, m-Bromoaniline
Molecular Formula: C6H6BrN
Molecular Weight: 172.02 g/mol
CAS Number: 591-19-5
Appearance: Pale yellow to light brown liquid or solid
Solubility: Slightly soluble in water; soluble in organic solvents like ethanol, ether, and chloroform
Structure and Reactivity
3-Bromoaniline features a benzene ring substituted with a bromine atom at the meta-position and an amino group (-NH2). This structural arrangement allows it to participate in a variety of organic reactions, including:
Nucleophilic substitution
Electrophilic aromatic substitution
Coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig)
Applications of 3-Bromoaniline
1. Pharmaceutical Intermediates
3-Bromoaniline is widely used in the synthesis of pharmaceutical compounds. It acts as a starting material or intermediate in the production of:
Analgesics
Anti-inflammatory agents
Antimicrobial drugs
2. Agrochemical Industry
It serves as a precursor in the manufacture of herbicides and pesticides, contributing to crop protection and agricultural productivity.
3. Dye and Pigment Manufacturing
3-Bromoaniline is also employed in the synthesis of azo dyes and pigments, where its amino group facilitates diazotization reactions.
4. Research and Development
It is a frequently used reagent in chemical research, particularly in the synthesis of heterocyclic compounds, molecular scaffolds, and catalysts.
Handling and Storage
Store in a cool, dry, and well-ventilated area
Keep container tightly closed and protected from light
Use appropriate PPE (gloves, goggles, lab coat) during handling
Avoid direct contact and inhalation; handle under a fume hood if necessary
Safety Information
Hazard Statements: Harmful if inhaled or absorbed through the skin; causes skin and eye irritation
Precautionary Measures: Use in a controlled environment with proper ventilation and protective equipment
Disposal: Must be disposed of according to local environmental regulations
Conclusion
3-Bromoaniline is a versatile aromatic amine widely used in pharmaceutical, agrochemical, and dye industries. Its reactivity and functional groups make it a valuable intermediate in the synthesis of complex molecules. With ongoing research and innovation, the demand for high-purity 3-Bromoaniline continues to grow across industries.
Looking to source 3-Bromoaniline? Contact us for bulk availability, COA, MSDS, and global shipping options.
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